JSCS - Vol 73, No 11

JSCS Vol 73, No. 11

Whole issue - PDF 2,990 KB

J. Serb. Chem. Soc. 73 (11) 1021–1025 (2008)
UDC *P. falciparum:546.174+547.567:615.281; JSCS–3783; doi: 10.2298/JSC0811021О; Original scientific paper

Ribofuranose as a carrier of tetraoxane and 4-AMinoquinoline antimalarial pharmacophores
IGOR M. OPSENICA, KIRSTEN K. SMITH*, LUCIA GERENA*, SANDRA GAICA** and BOGDAN A. SOLAJA
Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 158,11001 Belgrade, Serbia

*Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA

**Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, 11000 Belgrade, Serbia

(Received 13 February 2008)

Several tetraoxane and 4-AMinoquinoline molecules were prepared in order to exAMine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The AMinoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).

Keywords: tetraoxanes; 4-AMinoquinolines; malaria; P. falciparum.

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J. Serb. Chem. Soc. 73 (11) 1027–1037 (2008)
UDC *Resveratrol:663.253:615–188(497.11); JSCS–3784; doi: 10.2298/JSC0811027D; Original scientific paper

Trans- and cis-resveratrol concentration in wines produced in Serbia
SANJA DJEKIC, SLOBODAN MILOSAVLJEVIC, VLATKA VAJS*, SLOBODAN JOVIC**, ALEKSANDAR PETROVIC**, NINOSLAV NIKICEVIC**, VERICA MANOJLOVIC***, VIKTOR NEDOVIC** and VELE TESEVIC
Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia

*Institute for Chemistry, Technology and Metallurgy, University of Belgrade, Njegoseva 12, 11000 Belgrade, Serbia

**Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Zemun, Serbia

***Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia

(Received 3 March, revised 22 May 2008)

Resveratrol, which occurs in two isomeric forms, trans and cis, is a phytoalexin with numerous pharmacological activities, such as anti-cancer, antiviral, neuroprotective and anti-aging. Red wine is the main source of the compound and an easy way of including resveratrol in the human diet. In this study, the most popular commercial Serbian wines (red, white and rosé-type) were analyzed for their content of trans- and cis-resveratrol. The analysis was performed by HPLC with a UV detector. Prior to the injection, phenolic compounds were extracted onto a LiChrolut RP18 bonded silica cartridge. The concentration of trans-resveratrol ranged from 0.11 to 1.69 mg L^-1 and cis-resveratrol from 0.12 to 1.49 mg L^-1.

Keywords: trans/cis-resveratrol; wine; HPLC.

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J. Serb. Chem. Soc. 73 (11) 1039–1049 (2008)
UDC *Ambrosia artemisiifolia:638.138:615.28–188; JSCS–3785; doi: 10.2298/JSC0811039S; Original scientific paper

Chemical composition and biological activity of the acetone extract of Ambrosia artemisiifolia L. pollen
SLAVICA SOLUJIC, SLOBODAN SUKDOLAK, NENAD VUKOVIC, NEDA NICIFOROVIC and SNEZANA STANIC*

Department of Chemistry, Faculty of Science, University of Kragujevac, P.O. Box 12, 34000 Kragujevac, Serbia

*Department of Biology, Faculty of Science, University of Kragujevac, P.O. Box 12, 34000 Kragujevac, Serbia

(Received 10 December 2007, revised 21 May 2008)

In this study, the chemical components, antimicrobial and genotoxic biological activities of the acetone extract of Ambrosia artemisiifolia L. pollen were exAMined. Two lactones were identified: AMbrosin and artesovin. The antimicrobial activity of the acetone extract of A. artemisiifolia L. pollen was exAMined on ten different bacterial species using the disc diffusion method and the microdilution method in Mueller-Hinton broth dilution. The minimal inhibitory concentration of the acetone extract of A. artemisiifolia pollen varied between 1.25−6.50 mg mL^-1. The genotoxic effect of the acetone extract of A. artemisiifolia pollen on a eukaryotic model system Drosophila melanogaster was investigated using the SLRL test.

Keywords: Ambrosia artemisiifolia L.; pollen; extract; antimicrobial activity; genotoxicity.

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J. Serb. Chem. Soc. 73 (11) 1051–1061 (2008)
UDC 535–31+665.7.038.5–188:547.979.8+547.953; JSCS–3786; doi: 10.2298/JSC0811051C; Original scientific paper

UV-effects on antioxidant activity of selected carotenoids in the presence of lecithin estimated by DPPH test
DRAGAN CVETKOVIC and DEJAN MARKOVIC
Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, Leskovac, Serbia

(Received 19 March, revised 29 May 2008)

The effects of ultraviolet radiation (UV) on the antioxidant action of three selected carotenoids (β-carotene, lycopene and lutein) in the presence of a lipoidal lecithin mixture were studied by the DPPH (1,1-diphenyl-2-picrylhydrazyl) test. The test is based on the measurement of the decrease of the free DPPH radical absorbance at 517 nm caused by the antioxidant action of carotenoids, which appeared to be strongly affected by UV-action. The high-energy input of the involved UV-photons plays a major governing role.

Keywords: carotenoids; UV-light; lipids; antioxidants.

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J. Serb. Chem. Soc. 73 (11) 1063–1071 (2008)

UDC 542.9+547.571+547.551:542.913:66.092+548.7:615.281–188; JSCS–3787; doi: 10.2298/JSC0811063R; Original scientific paper

Designing, synthesis and spectral characterization of Schiff base transition metal complexes: DNA cleavage and antimicrobial activity studies

N. RAMAN, S. SYED ALI FATHIMA and J. DHAVEETHU RAJA

Research Department of Chemistry, VHNSN College, Virudhunagar-626 001, India

(Received 24 October 2007, revised 24 April 2008)

A new series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been designed and synthesized using a Schiff base (L) derived from 4-AMinoantipyrine, benzaldehyde and o-phenylenediAMine. The structural features were derived from their elemental analyses, magnetic susceptibility and molar conductivity, as well as from mass, IR, UV–Vis, ¹H-NMR and ESR spectral studies. The FAB mass spectral data and elemental analyses showed that the complexes had a composition of the ML type. The UV–Vis and ESR spectral data of the complexes suggested a square-planar geometry around the central metal ion. The magnetic susceptibility values of the complexes indicated that they were monomeric in nature. Antimicrobial screening tests were also performed against four bacteria, viz. Salmonella typhi, Staphylococcus aureus, Escherichia coli, and Bacillus subtilis and three fungi, viz. Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola. These data gave good results in the presence of metal ion in the ligand system. The nuclease activity of the above metal complexes shows that only the copper complex cleaves CT DNA in the presence of an oxidant.

Keywords: 4-AMinoantipyrine; benzaldehyde; o-phenylenediAMine; CT DNA; Schiff base; antimicrobial activity.

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J. Serb. Chem. Soc. 73 (11) 1073–1082 (2008)

UDC 661.8+547.362–32+549.766.321:615.281; JSCS–3788; doi: 10.2298/JSC0811073P; Original scientific paper

Transition metal complexes with oxygen donor ligands: a synthesis, spectral, thermal and antimicrobial study

VAIBHAV N. PATANGE, RAJENDRA K. PARDESHI and BALASAHEB R. ARBAD*

Department of Chemistry, Shri Chhatrapati Shivaji College, Omerga, Dist-Osmanabad – 413606, Maharashtra, India

*Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad – 431004, Maharashtra, India

(Received 14 November 2007, revised 6 June 2008)

Transition metal complexes of chalcones derived from the conden¬sation of 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione (dehydroacetic acid) and p-methoxybenzaldehyde (HL¹) or p-nitrobenzaldehyde (HL²) were synthesized and characterized by elemental analysis, conductometry, thermal analysis, magnetic measurements, IR, ¹H-NMR, UV–Vis spectroscopy and a microbial study. From the analytical and thermal data, the stoichiometry of the complexes was found to be 1:2 (metal:ligand). The molar conductance data revealed that all the metal chelates were non-electrolytes. The thermal stability of the complexes was studied by thermogravimetry and the decomposition schemes of the complexes are given. The ligands and their metal complexes were screened for antibacterial activity against Staphylococcus aureus and Escherichia coli, and fungicidal activity against Aspergillus flavus, Curvularia lunata and Penicillium notatum.

Keywords: dehydroacetic acid; chalcones; thermal study; ligand field parAMeters; antimicrobial study.

Full Article - PDF 348 KB

J. Serb. Chem. Soc. 73 (11) 1083–1112 (2008)

UDC 544.4/.6.004.2+66.022.362:546.82+621.3.032.2:544.773.42; JSCS–3789; doi: 10.2298/JSC0811083P; Authors’ Review

Authors’ Review

Electrocatalytic properties and stability of titanium anodes activated by the inorganic sol–gel procedure

VLADIMIR V. PANIC and BRANISLAV Z. NIKOLIC*

ICTM – Centre for Electrochemistry, Njegoševa 12, 11000 Belgrade, Serbia

*Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia

(Received 3 March 2008, 2 September 2008)

The properties of activated titanium anodes, RuO₂–TiO₂/Ti and RuO₂–TiO₂–IrO₂/Ti, prepared from oxide sols by the sol–gel procedure, are reviewed. RuO₂ and TiO₂ sols were synthesized by forced hydrolysis of the corresponding chlorides in acid medium. The morphology of the prepared sols was investigated by transmission electron microscopy. The chemical composition of the RuO₂ sol was determined by X-ray diffraction and thermogravimetric analysis. The loss of electrocatalytic activity of a RuO₂–TiO₂/Ti anode during an accelerated stability test was investigated by exAMination of the changes in the electrochemical characteristics in the potential region of the chlorine and oxygen evolution reaction, as well as on the open circuit potential. These electrochemical characteristics were investigated by cyclic voltAMmetry, electrochemical impedance spectroscopy and polarization measurements. The changes in electrochemical characteristics of the anode prepared by the sol–gel procedure were compared to the changes registered for an anode prepared by the traditional thermal decomposition of metal chlorides. The comparison indicated that the main cause for the activity loss of the sol–gel prepared anode was the electrochemical dissolution of RuO₂, while in the case of thermally prepared anode the loss was mainly caused by the formation of an insulating TiO₂ layer in the coating/Ti substrate interphase. The results of an accelerated stability test on RuO₂–TiO₂/Ti and RuO₂–TiO₂–IrO₂/Ti anodes showed that the ternary coating is considerably more stable than the binary one, which is the consequence of the greater stability of IrO₂ in comparison to RuO₂.

Keywords: activated titanium anodes; oxide sols; coating morphology; electrocatalytic properties; anode stability.

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J. Serb. Chem. Soc. 73 (11) 1113–1122 (2008)

UDC 546.193+547.461.2:543.555:541.132.3; JSCS–3790; doi: 10.2298/JSC0811113O; Original scientific paper

Conductometric and pH metric investigations of the oxalic acid and NaAsO₂ reaction

MIRJANA V. OBRADOVIC, SLAVICA M. SUNARIC*, SNEZANA S. MITIC and DRAGAN S. VESELINOVIC**

Department of Chemistry, Faculty of Natural Sciences and Mathematics, University of Nis, Visegradska 33, P.O. Box 224, Serbia

*Faculty of Medicine, Department of Pharmacy, University of Nis, Bulevar dr Zorana Djindjica 81

**Faculty of Physical Chemistry, University of Belgrade, P.O. Box 550, Serbia

(Received 10 January, revised 15 May 2008)

The reaction between NaAsO₂ and oxalic acid was studied by pH-metric and conductometric measurements, applying the methods of continual variation and pH-metric and conductometric titration. It was found that oxalic acid forms a complex anion of the type [AsOC₂O₄]^-. The relative stability constant of the complex at ionic strengths, I, of 0.10 (log K_r = 4.70), 0.20 (log K_r = 4.51), 0.50 (log K_r = 4.24) and 0 (log K⁰_r = 5.05) and thermodynAMic para¬meters were calculated using the data obtained by pH-metric measurements at 25.0±0.1 °C (DH = 10.5 kJ mol^-1, DG = –29.0 kJ mol^-1, DS = 133 J mol^-1 K^-1).

Keywords: arsenic(III); oxalic acid; complex; conductometry; pH-metry.

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J. Serb. Chem. Soc. 73 (11) 1123–1135 (2008)

UDC 57.012.2.000.57:66.022.34.002.2:541.183; JSCS–3791, doi: 10.2298/JSC0811123L; Original scientific paper

Microstructured surfaces engineered using biological templates: a facile approach for the fabrication of superhydrophobic surfaces

DUSAN LOSIC

University of South Australia, Ian Wark Research Institute, Mawson Lakes CAMpus, Adelaide, SA 5095, Australia

(Received 2 March, revised 27 May 2008)

The fabrication of microstructured surfaces using biological templates was investigated with the aim of exploring of a facile and low cost approach for the fabrication of structured surfaces with superhydrophobic properties. Two soft lithographic techniques, i.e., replica moulding and nano-imprinting, were used to replicate the surfaces of a biological substrate. Leaves of the Agave plant (Agave attenuate), a cost-free biological template, were used as a model of a biosurface with superhydrophobic properties. The replication process was performed using two polymers: an elastomeric polymer, poly(dimethylsiloxane) (PDMS), and a polyurethane (PU) based, UV-curable polymer (NOA 60). In the first replication step, negative polymer replicas of the surface of leaves were fabricated, which were used as masters to fabricate positive polymer replicas by moulding and soft imprinting. The pattern with micro and nanostructures of the surface of the leaf possesses superhydrophobic properties, which was successfully replicated into both polymers. Finally, the positive replicas were coated with a thin gold film and modified with self-assembled monolayers (SAMs) to verify the importance of the surface chemistry on the hydrophobic properties of the fabricated structures. Wetting (contact angle) and structural (light microscopy and scanning electron microscopy) characterisation was performed to confirm the hydrophobic properties of the fabricated surfaces (> 150°), as well as the precision and reproducibility of the replication process.

Keywords: superhydrophobic surfaces; lotus-effect; replica moulding; nano-imprinting; Agave attenuate.

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J. Serb. Chem. Soc. 73 (11) 1137–1138 (2008)

UDC *Mendeleev 54(083):930; JSCS–3792; Book Review

BOOK REVIEW

THE PERIODIC TABLE - Its story and its significance, Author: ERIC R. SCERRI

IVAN JURANIC

Faculty of Chemistry University of Belgrade, Serbia

Full Article - PDF 185 KB

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