JSCS Vol 72, No. 3
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J. Serb.
Chem. Soc. 72 (3) 205–214 (2007)
UDC 547.821.595:543.878, JSCS–3550, doi: 10.2298/JSC0703205A; Original scientific paper
Investigation
of the reactivity of 4-pyrimidinecarboxylic, 6-hydroxy-4-pyrimidinecarboxylic
and 5-hydroxyorotic acids with diazodiphenylmethane
in various alcohols. Part III
FATHI H. ASSALEH, ALEKSANDAR D.
MARINKOVIC, SASA Z. DRMANIC and BRATISLAV Z. JOVANOVIC
Department of Organic Chemistry, Faculty
of Technology and Metallurgy, University of Belgrade, Karnegijeva
4, P.O. Box 3503, 11120 Belgrade, Serbia
(Received 14 July, revised
Rate constants for the reaction of diazodiphenylmethane
(DDM) with 4-pyrimidinecarboxylic, 6-hydroxy-4-pyrimidinecarboxylic and
5-hydroxyorotic acids were determined in twelve protic
solvents at 30 °C using the well known
UV-spectrophotometric method. The second order rate contants
for the exAMined
acids were correlated using the appropriate solvent parAMeters by the
equation log k = log k0 + af(e) + bs * + cngH were f(e) is the Kirkwood function of relative permittivity [(e–l)/(2e + 1 )], s * is the Taft polar constant for the alkyl group R in
the alcohol ROH, and nyH is themumber
of hydrogen atoms in the g-position in the alcohol. The results obtained for the
investigated acids were compared with the corresponding results for benzoic, 2-
and 3-hydroxybenzoic acids and the influence of the structure of the
investigated acids on the reactivity in hydroxylic
solvents is discussed. It was also possible to evaluate and distinguish the
specific and non-specific solvent effects and their influence on the reaction
rate.
Keywords:
rate constants, 5-hydroxyorotic acid, 6-hydroxy-4-pyrimidinecarboxylicacid,
4-pyrimidinecarboxylic acid.
Full Article - PDF 116 KB
J. Serb.
Chem. Soc. 72(3) 215–224 (2007)
UDC 547.272+54–36:615.281:543.42
JSCS–3551 doi: 10.2298/JSC0703215Y; Original scientific paper
Synthesis
and antimicrobial activity of new crown ethers of Schiff base type
MUSTAFA YILDIZ, AŞKIN KĺRAZ* and BAŞARAN DÜLGER**
Department of Chemistry, Faculty of Arts
and Sciences,
*Department of Natural Sciences, Faculty
of Education,
**Department of Biology, Faculty of Arts
and Sciences,
(Received 27 January, revised
New crown ether ligands of the Schiff base type (4a–d) were synthesized by the reaction
of 2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde and
2-hydroxy-1-naphthaldehyde with 6,7-dihydro-13H-dibenzo [e,h]
[1,4]dioxonin-2,11-diAMine (3). The structures
of ligands were investigated by elemental analysis as well as IR, UV–visible, 1H-NMR,
13C-NMR and MS spectroscopic data. The antimicrobial and anti-yeast
activities of the ligands were screened in
vitro against the organisms Escherichia
coli ATCC 11230, Staphylococcus
aureus ATCC 6538, Klebsiella pneumoniae UC57, Micrococcus luteus La 2971, Proteus vulgaris ATCC 8427, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis
CCM 2067, Bacillus cereus ATCC 7064, Listeria monocytogenes ATCC 15313, Candida albicans
ATCC 10231, Kluyveromyces fragilis NRRL
2415, Rhodotorula rubra DSM
70403, Debaryomyces hansenii DSM
70238 and Hanseniaspora guilliermondii
DSM 3432.
Keywords:
crown ether, Schiff base, antimicrobial activity, spectroscopy.
Full Article - PDF 126 KB
J. Serb.
Chem. Soc. 72 (3) 225–234 (2007)
UDC 612.438+57.088+547.466.1:57–188,
JSCS–3552, 10.2298/JSC0703225R; Original
scientific paper
Isolation
of thymus gland fractions and the determination of their biological activity
MILENA RADETA, JASNA NOVAKOVIC, MILANKA
VICO-STEVANOVIC, SLOBODANKA SIMIC and ALEKSANDAR PIROZKOV*
Galenika a.d. – Institute for
Research and Development, Batajnicki drum bb, 11080
*Galenika a.d. - Quality Control Department, Batajnicki
drum bb, 11080
(Received
A calf thymus extract was prepared and fractionated
into lipid and non-lipid fractions. The non-lipid fraction was isolated from
the calf thymus extract using the Folch method. The
components isolated from the non-lipid fraction were characterized by IR, NMR,
biuret and HPLC method. The results of the analyses indicated the presence of
peptides. The lipid fraction contained phospholipids, glycolipids and neutral
lipids. The biological activity of both the isolated lipid and peptide
fractions was determined by the in vivo hemolytic plaques method in Wistar rats with an involuted
thymus. The peptide and phospholipid fractions of the thymus extract showed a
significant increase of hemolytic plaques. The glycolipid and neutral lipid
fraction failed to express a significant immunological response.
Keywords: thumus gland, peptides, immunomodulators, hemolytic plaques method.
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J. Serb. Chem. Soc. 72 (3) 235–250
(2007)
UDC
547.912+66.085.3+547.953:66.094.3–92:541.459, JSCS–3553, 10.2298/JSC0703235C; Original scientific paper
Amarginal
contribution of selected carotenoids to the supression
of UV-irradiation-induced lecithin peroxidation in hexane solution
DRAGAN CVETKOVIC and DEJAN MARKOVIC
Faculty of Technology, 16000
(Received
The aim of this work was to study the anticipated
antioxidant role of four selected carotenoids in mixtures with lecithin lipoidal compounds in hexane solution, under continuous
UV-irradiation in three different ranges (UV-A, UV-B and UV-C). Two carotenes (b-carotene and licopene) and
two xantophylls (lutein and neoxanthin)
were employed to control the lipid peroxidation process generated by
UV-irradiation, by scavenging the involved free radicals. The results show that
while carotenoids undergo a substantial, structural dependent destruction
(bleaching), which is highly dependent on energy of the UV-photons, their
contribution to the expected suppression of lecithin peroxidation is of
marginal importance, not exceeding a maximum of 20%. The marginal antioxidant behaviour has been attributed to a highly unordered hexane
solution, where the scavenging action of the carotenoids becomes less
competitive.
Keywords: carotenoids, lipids, UV-irradiation, bleaching,
peroxidation.
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J. Serb. Chem. Soc. 72 (3) 251–257
(2007)
UDC 547.77+547.551.42+546.562:542.913,
JSCS–3554, doi: 10.2298/JSC0703251Z; Original scientific paper
Coordination compounds of Cu(II) with some
substituted 2-(3,5-dimethyl-pyrazol-1-yl)-methyl-acetanilides
as ligands CHRISTINA
ZALARU, MIRCEA IOVU*, FLORICA ZALARU**, AURELIAMEGHEA***, MARIANA GIURGINCA***
and MARIA PLAVETI****
*University of
Medicine and Pharmaceutic "Carol Davila", Department of Organic
Chemistry, 6 Traian Vuia
St. Bucharest, Romania
**University of
Bucharest, Faculty of Chemistry, Department of Inorganic Chemistry, 23 Dumbrava, Rosie, St., Bucharest, Romania
***
****Institute of
Organic Chemistry "C.D. Nenitescu",
Romanian Academy, Spl. Independentei
202B,
(Received
New complexes of Cu(II) with some substituted
2-(3,5-dimethyl-pyrazol-1-yl)-methyl-acetanilides (L)
hae been synthesized. The complex compounds, CuL4X2
(where X- = Cl,Br, CH3COO) were
characterized by elemental analysis, as well as IR, UV-VIS, EPR spectroscopy.
The study evidenced the influence of the position of the methyl group on the
benzene ring and also of the anions on the physical properties of the
compounds.
Keywords: pyrazol-1-yl-acetanilides,
Cu(II) coordination compounds.
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J. Serb. Chem. Soc.
72 (3) 259–264 (2007)
UDC
547.2+547.571+547.551+542.9:542.913, JSCS–3555, doi:
10.2298/JSC0703259S; Original scientific paper
The template synthesis,
spectral characterization and thermal behaviour of
new binuclear Schiff base complexes derived from N-AMinopyrimidine
with 2,3-butandion
MEHMET SÖNMEZ and MEMET ŞEKERCI*
Department of Chemistry, Faculty of Science
and Arts, Yüzüncü Yil,
University, 65080, Van, Turkey
*Department of Chemistry, Faculty of Science
and Arts, Firat University, 23169,
(Received 23 September 2005, revised 5 Juni 2006)
A new series of two types
of acyclic binuclear Schiff base complexes, prepared by the template
condensation of N-AMinopyrimidine and
2,3-butandion in the presence of Cu(II), Ni(II), Co(II) and Zn(II) in n-BuOH solution, were analyzed and characterized by elemental
analyses, IR and electronic spectroscopy, conductivity and magnetic
measurements. From the conductivity measurements, it is concluded that the
complex of NiII is a 1:1 type of
electrolyte. All the complexes have sub-normal magnetic moments in accordance
with their binuclear nature. The thermal behaviour of
the complexes was studied by thermogravimetry.
Keywords:
acyclic Schiff base complexes, Cu(II), Co(II), Ni(II), Zn(II) template synthesis.
Full Article -
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J. Serb. Che. Soc. 72 (3) 265–273 (2007)
UDC
547–3:537.12:54.02:539.193:546.11, JSCS–3556, doi:
10.2298/JSC0703265P; Original scientific paper
Electronic
structure of planar-quasicycled organic molecules
with intrAMolecular hydrogen bond
ALEXEI N. PANKRATOV* and
ALEXEI V. SHALABAY
Department of Chemistry, N.
G. Chernyshevskii Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia
(Received 17 February,
revised 30 Maj 2006)
By means of the HF/6-311G(d,p) method, the electronic structure of the series of
organic molecules, AMong which are malonaldehyde, acetylacetone, thiomalonaldehyde,’the derivatives of aniline 2-XC6H4NH2,
phenol 2-XC6H4OH, benzenethiol
2-XC6H4SH (X = CHO, COOH, COO-, NO, NO2, OH,
OCH3, SH, SCH3, F, Cl, Br), 8-hydroxyquinoline, 8-mercaptoquinoline,
tropolone, has been studied. The intrAMolecular
hydrogen bond (IHB) has been established to lead to a local electron
redistribution in quasicycle, and primarily to the
electron density transfer between the direct IHB participants – from the
hydrogen atom toward the proton-aceptor atom. On
forming the IHB of the S–H···O type, the electron density in general decreases
on the sulphohydryl hydrogen atom and increases on
the sulphur atom.
Keywords: intrAMolecular hydrogen bond, electronic
structure, organic compounds with planar quasicycle,
quantum chemical ab initio study, dipole moment.
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J. Serb. Chem. Soc. 72 (3)
275–287 (2007)
UDC 621.359.3+667.632.046:669.295, JSCS–3557,
doi: 10.2298/JSC070375D; Original scientific
paper
Electrophoretic deposition
and thermal treatment of boehmite coatings on
titanium
MARIJA S. DJOSIC, VESNA B.
MISKOVIC-STANKOVIC* and VLADIMIR V. SRDIC**
Institute for Technology of Nuclear and Other
Mineral Raw Materials, Franse d'Eperea
86, 11000
*Faculty of Technology and Metallurgy,
University of Belgrade, Karnegijeva 4, P. O. Box
3503, 11120 Belgrade, Serbia
**Department of Materials Engineering,
Faculty of Technology, University of Novi Sad, Bulevar
Cara Lazara 1, 21000 Novi Sad, Serbia
(Received 27 March, revised 29 June 2006)
An aqueous boehmite
sol was prepared by the peptization of Al(OH)3.
The electrophoretic deposition of boehmite coatings
on titanium from the aqueous sol was performed at a constant voltage (from 1.0
to 10 V) and for a constant deposition time (from 10 to 30 min). Increasing the
applied voltage and deposition time increased the mass of the boehmite coating. It was shown that boehmite
coatings of maximum thickness, low porosity and good adhesion can be formed at
lower deposition voltages and longer deposition times. The boehmite
powder, obtained by drying the prepared aqueous sol, and the boehmite coatings were thermally treated at 1000 °C and
1300 °C with a holding period of 1 h at the maximum temperature. X-Ray
diffraction analysis of the thermally treated sAMples confirmed the existence
of g-Al2O3 and a-Al2O3
phases, respectively, while scanning electron microscopy revealed the
graininess of the structure of the a-Al2O3
coatings treated at 1300 °C, indicating a significantly lower sintering
temperature of the boehmite coating obtained by
electrophoretic deposition.
Keywords:
boehmite sol, electrophoretic deposition, boehmite coating, titanium, thermal treatment.
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J. Serb. Chem. Soc. 72 (3)
289–297 (2007)
UDC 66.061+546.47+547.441–036.7:541.12.012,
JSCS– 3558, doi: 10.2298/JSC070389B; Original
scientific paper
The extraction of Zn(II) in
aqueous PEG (1550) – (NH4)2SO4 two-phase
system using Cl– ions as extracting agent
LAURA BULGARIU and DUMITRU BULGARIU*
Department of Management and Environmental
Engineering, Faculty of Chemical Engineering, Technical University "Gh. Asachi", 700050 Iasi,
Romania
*Department of Geology and Geochemistry,
Faculty of Geography and Geology, "Al. I. Cuza"
University, 700050
(Received 25 November 2005)
The extraction of Zn(II) in an aqueous PEG
(1550) – (NH4)2SO4 two-phase system as a
function of several experimental parAMeters was studied. PEG-based aqueous
two-phase systems are composed of two immiscible phases: a polymer-rich phase
and a salt-rich phase, which can be used for extraction experiments. In the
absence of a suitable extracting agent, for the system consisting of a mixture
of equal volumes of 40 mass% PEG and 40 mass% (NH4)2SO4
aqueous solutions, Zn(II) remained predominantly in the salt-rich phase.
Variation of the pH of the salt stock solution did not change very much the
extraction efficiency. By adding chloride ions, an enhancement of the Zn(II)
extraction was observed. The Zn(II) extraction efficiency in presence of Cl-
depends on the acidity of the salt stock solution and on the concentration of
chloride ions added into the system.
Keywords:
aqueous two-phase system, Zn(II) extraction, polyethylene glycol, (NH4)2SO4,
chloride ions.
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J. Serb. Chem. Soc. 72 (3)
299–310 (2007)
UDC 546.562+543.4/.5+628.1.033:547.412.123,
JSCS–3559, doi: 10.2298/JSC0703299R; Short communication
Short
communication
Extractive spectrophotometric determination of
copper(II) in water and alloy sAMples with 3-methoxy-4-hydroxy
benzaldehyde-4-bromophenyl hydrazone (3,4-MHBBPH)
D. REKHA, K. SUVARDHAN, K. SURESH KUMAR, P. REDDYPRASAD,
B. JAYARAJ* and P. CHIRANJEEVI
Environmental Monitoring Laboratories,
Department of Chemistry, S. V. University, Tirupati-517502, AP India
*Department of Mathematics, S. V. University,
Tirupati-517502, AP India
(Received 7 November 2005, revised 10 May
2006)
A facile, sensitive and selective extractive spectrophotometricmethod was developed for the
determination of copper(II) in various water and alloy sAMples using a newly
synthesized reagent, 3-methoxy-4-hydroxy benzaldehyde 4-bromophenyl hydrazone (3,4-MHBBPH). Copper(II) forms a orange colored complex with (3,4-MHBBPH) in acetate buffermedium (pH 4) which increases the sensitivity and the
complexwas extracted into chloroform. Under optimum
conditions, the maximum absorption of the chloroform extract was measured at
462 nm. The Beer law was obeyed in the range of 0.20 to 4.0 mg
ml-1 of copper. The molar absorptivity and the Sandell's
sensitivity of the complex were 2.0520 ´ 104 mol-1
cm-1 and 0.2540 mg cm-2, respectively. The detection
limit was found to be 0.0270 mg mL-1. Adetailed study of various interfering ions made the method
more sensitive. The method was successfully applied for the determination of
Cu(II) in water and alloy sAMples. The performance of the present method was
evaluated in terms of Student 't' test and Variance ratio 'f ' test, which
indicate the significance of the present method over reported methods.
Keywords: copper(II), 3-metoxy-4-hydroxy
benzaldehyde 4-bromophenyl hydrazone (3,4-MHBBPH),
spectrophotometry, water and alloy sAMples.
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